Proteus Syndrome: Background information when reading No One Is Talking About This

Summary |  Excerpt |  Reviews |  Beyond the Book |  Readalikes |  Genres & Themes |  Author Bio

No One Is Talking About This

by Patricia Lockwood

No One Is Talking About This by Patricia Lockwood X
No One Is Talking About This by Patricia Lockwood
  • Critics' Opinion:

    Readers' Opinion:

     Not Yet Rated
  • First Published:
    Feb 2021, 224 pages

    Paperback:
    Feb 2022, 224 pages

    Genres

  • Rate this book


Book Reviewed by:
Norah Piehl
Buy This Book

About this Book

Proteus Syndrome

This article relates to No One Is Talking About This

Print Review

Midway through Patricia Lockwood's novel No One Is Talking About This, the unnamed protagonist learns that her sister's baby has been diagnosed with Proteus syndrome. You might recognize this as the condition believed to have affected Joseph Merrick, the so-called Elephant Man, whose late-19th-century life has been dramatized in a 1979 play and a 1980 Oscar-nominated film.

Merrick's medical condition was not theorized to have been Proteus syndrome until nearly a century after his death. The condition was first reported in the late 1970s and is an extremely rare disorder, with only around 200 cases recorded worldwide. It is characterized by a highly variable and unpredictable overgrowth of skin, bones, muscles, fatty tissues and blood vessels.

Proteus syndrome is named after the Greek sea-god Proteus, who could see the future and change his shape at will, and who plays a role in Homer's Odyssey. Proteus was a "shepherd" for Poseidon's flocks of sea creatures, and he is Poseidon's son in some versions of mythological tales. His name is also the basis for the adjective "protean," meaning both able to change and versatile.

It is possible to diagnose Proteus syndrome before a child's birth based on ultrasound observations; however, most people with the condition do not carry any physical manifestations of it at birth. Instead, tumors and other atypical growth patterns are likely to arise in early childhood and continue progressing throughout an affected individual's lifetime. Those with the disorder have a reduced life expectancy due to its side effects, which include pulmonary embolisms and other blood clotting issues. They can also experience chronic pain and arthritis due to limb and organ overgrowth.

Proteus syndrome is caused by a mosaic variant in a gene called AKT1, a mutation that takes place during development rather than being inherited from a parent. Mosaicism occurs when a single individual has two or more genetically different cell sets in their body. In the case of Proteus syndrome, this appears to contribute to the highly variable characteristics of the disorder, as well as its mosaic, or patchy, presentation — affected and unaffected areas develop in a seemingly random pattern.

There is no single treatment for Proteus syndrome; rather, therapies are directed to the particular manifestations of the condition in patients and their specific medical needs. Some patients require multiple orthopedic surgeries to counteract bone overgrowth, especially when that growth interferes with joint function. A study appearing in the American Journal of Human Genetics suggests that a cancer drug, miransertib, can help control pain and lesions in people with Proteus syndrome. Like many rare diseases, Proteus syndrome is less well understood and intensively studied than better known disorders. Although there is no cure, ongoing research appears to be generally focused on improving quality of life for those affected by this condition.

Filed under Medicine, Science and Tech

Article by Norah Piehl

This article relates to No One Is Talking About This. It first ran in the February 17, 2021 issue of BookBrowse Recommends.

This review is available to non-members for a limited time. For full access become a member today.
Membership Advantages
  • Reviews
  • "Beyond the Book" articles
  • Free books to read and review (US only)
  • Find books by time period, setting & theme
  • Read-alike suggestions by book and author
  • Book club discussions
  • and much more!
  • Just $39 for 12 months or $12 for 3 months.
  • More about membership!

Join BookBrowse

and discover exceptional books
for just $3.25 per month.

Find out more


Top Picks

  • Book Jacket: We Had to Remove This Post
    We Had to Remove This Post
    by Hanna Bervoets
    It's not about money. Kayleigh, the protagonist and narrator of We Had to Remove This Post, a newly ...
  • Book Jacket: River of the Gods
    River of the Gods
    by Candice Millard
    The Nile River has provided vital resources for millennia, serving as a source of water, food and ...
  • Book Jacket: Horse
    Horse
    by Geraldine Brooks
    Geraldine Brooks creates a powerful backstory for 19th-century thoroughbred racehorse Lexington, ...
  • Book Jacket: Notes on Your Sudden Disappearance
    Notes on Your Sudden Disappearance
    by Alison Espach
    Notes on Your Sudden Disappearance will make you ache for a loss you didn't experience as you relate...

Book Club Discussion

Book Jacket
Hamnet
by Maggie O'Farrell
"Of all the stories...about Shakespeare’s life, [Hamnet] is so gorgeously written that it transports you."
The Boston Globe

Members Recommend

  • Book Jacket

    Fruiting Bodies
    by Kathryn Harlan

    A genre-bending debut collection of stories full of desire, wisdom, and magic blooming amidst decay.

  • Book Jacket

    Daughters of the Flower Fragrant Garden
    by Zhuqing Li

    A beautifully woven family memoir that coalesces into a vivid history of two very different Chinas.

Win This Book!
Win Where the Crawdads Sing

Win a signed copy of Where the Crawdads Sing

In celebration of the movie release on July 15, we have three signed copies to give away.

Enter

Wordplay

Solve this clue:

T O Thing W H T F I F I

and be entered to win..

Books that     
entertain,
     engage

 & enlighten

Visitors can view some of BookBrowse for free. Full access is for members only.

Join Today!

Your guide toexceptional          books

BookBrowse seeks out and recommends the best in contemporary fiction and nonfiction—books that not only engage and entertain but also deepen our understanding of ourselves and the world around us.