Achondroplasia: Background information when reading Big Girl Small

Summary |  Excerpt |  Reading Guide |  Reviews |  Beyond the Book |  Readalikes |  Genres & Themes |  Author Bio

Big Girl Small

A Novel

by Rachel DeWoskin

Big Girl Small
  • Critics' Opinion:

    Readers' Opinion:

  • First Published:
    May 2011, 304 pages
    Paperback:
    Jul 2012, 304 pages

  • Rate this book


Book Reviewed by:
Norah Piehl

Buy This Book

About this Book

Beyond the Book:
Achondroplasia

In Rachel DeWoskin's novel, Big Girl Small, Judy Lohden has achondroplasia, a genetic bone growth disorder that results in short-limbed dwarfism (responsible for about 70% of all dwarfism cases). The word "achondroplasia" literally means "without cartilage formation," however, the term is a bit of a misnomer as the body of a person with achondroplasia is able to form cartilage but then fails to convert it to bone (especially in the long bones, i.e. arms and legs). This happens when there is a mutation of the FGFR3 gene (the gene responsible for producing a protein that develops and maintains the growth of bone and brain tissue), which then causes disruptions in skeletal development.

Affecting 1 out of every 15,000 - 40,000 births, a person can get the gene one of two ways - via genetic mutation or by inheriting the gene from one or both parents. According to the U.S. National Library of Medicine, achondroplasia "is inherited in an autosomal dominant pattern, which means one copy of...

Members Only

BookBrowse's reviews and backstories are a members-only benefit. Full information is available on books for a limited time when they are featured as "Editor's Choices" - but that time has now elapsed for this book.

Join Today


Member Login


Library Patrons

One-Month Free Membership

Join Today!

Editor's Choice

  • Book Jacket: Here I Am
    Here I Am
    by Jonathan Safran Foer
    With almost all the accoutrements of upper middle-class suburban life, Julia and Jacob Bloch fit the...
  • Book Jacket: Harmony
    Harmony
    by Carolyn Parkhurst
    In previous novels such as The Dogs of Babel and Lost and Found, Carolyn Parkhurst has shown herself...
  • Book Jacket: Commonwealth
    Commonwealth
    by Ann Patchett
    Opening Ann Patchett's novel Commonwealth about two semi-functional mid-late 20th Century ...

First Impressions

  • Book Jacket

    Darling Days
    by iO Tillett Wright

    A devastatingly powerful memoir of one young woman's extraordinary coming of age.

    Read Member Reviews

  • Book Jacket

    The Tea Planter's Wife
    by Dinah Jefferies

    An utterly engrossing, compulsive page-turner set in 1920s Ceylon.

    Read Member Reviews

Book Discussions
Book Jacket
Circling the Sun
by Paula McLain

An intoxicatingly vivid portrait of colonial Kenya and its privileged inhabitants.

About the book
Join the discussion!
Win this book!
Win Blood at the Root

Blood at the Root

"A gripping, timely, and important examination of American racism."
- PW Starred Review

Enter

Word Play

Solve this clue:

D C Y C Before T A H

and be entered to win..

Books that     
entertain,
     engage

 & enlighten

Visitors can view some of BookBrowse for free. Full access is for members only.

Join Today!

Your guide toexceptional          books

BookBrowse seeks out and recommends books that we believe to be best in class. Books that will whisk you to faraway places and times, that will expand your mind and challenge you -- the kinds of books you just can't wait to tell your friends about.

 
X

Free Weekly Newsletter

Keep up with what's happening in the world of books:
Reviews, previews, interviews and more!



Spam Free: Your email is never shared with anyone; opt out any time.