Meaning:
The nature of things (usually referring to humans) is unchangeable - just as the leopard cannot change its spots, a person cannot change their nature.
Background:
And if you ask yourself,
'Why has this happened to me?"
it is because of your many sins
that your skirts have been torn off
and your body ill-treated.
Can the Ethiopian change his skin
or the leopard his spots?
Neither can you do good
who are accustomed to doing evil.
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